AC is safe, practical, and effective during resection of supratentorial lesions of diverse pathological range and location. AC was well tolerated and showed a low rate of complications, with the benefit of maximal tumour excision and a potentially better patient outcome. AC in selected patients is an effective, safe and practical procedure, which is accompanied with a short hospital and ICU length of stay. AC patients showed a significantly better neurological outcome, faster discharge times and an uneventful surgery. Implementation of the new anaesthesiological approach was successful, with a low operative morbidity and rate of anaesthesia complications, short surgery time, and well tolerance by the patients. 2 groups (eloquent cortex AC n = 511, non-eloquent cortex AC n = 99) To elucidate the outcomes and potential advantages associated with AC for supratentorial tumour resection, treated by one neurosurgeon. No To analyse the individual anaesthetic management, intraoperative complications and postoperative outcome of patients undergoing AC. The safety and effectiveness of AC in 25 patients should be described. To assess the safety and effectiveness of AC in comparison to GA for lesions close to the eloquent cortex. Description of a new anaesthesiological protocol and patient outcomes for the first patients undergoing AC surgery in this institution. AC group showed less PONV and pain postoperatively. AC provides adequate sedation, analgesia and a smooth wake-up during the period of purchase MLN9708 neurological monitoring with stable haemodynamic and acceptable respiratory parameters compared to general anaesthesia. Blood pressure was lower in the AC group during application of head clamp pins and emergence and the AC group required less vasopressors intraoperatively. Temporary episodes of desaturation and hypercapnia occurred more often in the AC group. Preoperative resting state MEG connectivity analysis is a useful noninvasive tool to evaluate the functionality of the tissue surrounding tumors within eloquent areas, and could potentially contribute to surgical planning and patient counseling.Tumours in eloquent brain areas, otherwise considered as inoperable. Maps showing increased resting-state functional connectivity within the tumor area had a positive predictive value of 64% for finding language, motor, or sensory cortical sites during IES mapping. Maps with decreased resting-state functional connectivity in the entire tumor area had a negative predictive value of 100% for absence of eloquent cortex during IES. The cortical connectivity pattern near the tumor was compared to the IES results. IES mapping was performed in all subjects. Neural activity was estimated using adaptive spatial filtering algorithms, and the mean imaginary coherence between the rest of the brain and voxels in and around brain tumors were compared to the mean imaginary coherence between the rest of the brain and contralesional voxels as an index of functional connectivity. Resting-state whole-cortex MEG recordings were obtained from 57 consecutive subjects with focal brain tumors near or within motor, sensory, or language areas. The aim of the present work is to evaluate the value of preoperative magnetoencephalography (MEG) imaging of functional connectivity to predict the results of intraoperative electrical stimulation (IES) mapping, the clinical gold standard for neurosurgical localization of functional areas. If maximal resection is desired without inducing postoperative neurological deficits, a detailed knowledge of the functional topography in and around the tumor is crucial. Resection of brain tumors adjacent to eloquent areas represents a challenge in neurosurgery.
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